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Howard LeWine, assistant professor of medicine at Harvard Medical School
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This phenomenon may be partly explained by biological differences such as variations in sex hormone levels, pancreatic -cell composition, and gene expression patterns related to insulin secretion and glucose metabolism [49]
The FDA approved it in 2012 for chronic weight management in adults with a BMI of 30 or greater, or a BMI of 27 or greater with at least one weight-related comorbidity such as high blood pressure, type 2 diabetes, or high cholesterol
However, a healthcare professional will need to assess suitability for PDE5 inhibitors, checking for contraindications (such as nitrate medications or certain alpha-blockers) and evaluating cardiovascular fitness for sexual activity
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